More on prognostic significance of FLT3/ITD size in acute myeloid leukemia (AML).

dependent on iron delivery to developing erythrocytes; increased transferrin saturation may be essential to deliver iron when DMT1 activity is diminished. Thus, even if medications that increase hepcidin levels become available for treatment of iron overload, they may not benefit DMT1 patients because increased plasma hepcidin level would limit release of iron into the bloodstream, decreasing serum iron level and transferrin saturation, further limiting available iron for hemoglobin synthesis. Removing excess iron is probably the only viable treatment for iron overload in these patients.